BDBM703786 US20240368150, Example 184::methyl 1-[5-[(3R)-3- amino-5-[(4-chloro- phenyl)methyl]-8- fluoro-1,1,4-trioxo-2,3- dihydro-1λ6,5-benzo- thiazepin-7-yl]-1,3,4- oxadiazol-2-yl]-3- azabicyclo[3.1.1]- heptane-3-carboxylate

SMILES COC(=O)N1CC2CC(c3nnc(-c4cc5c(cc4F)S(=O)(=O)C[C@H](N)C(=O)N5Cc4ccc(Cl)cc4)o3)(C2)C1

InChI Key InChIKey=JALLRDCKJHNJEL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 703786   

TargetDiacylglycerol kinase alpha(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703786(methyl 1-[5-[(3R)-3- amino-5-[(4-chloro- phenyl)me...)
Affinity DataIC50: 244nMAssay Description:DGK α and ζ kinase use ATP to phosphorylate the substrate 1,2-dilauroyl-sn-glycerol (DLG, incorporated in the liposomes). ATP is converted to ADP as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703786(methyl 1-[5-[(3R)-3- amino-5-[(4-chloro- phenyl)me...)
Affinity DataIC50: 290nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent