BDBM703778 (3R)-3-amino-7-[5-(1-amino-2,2,2-trifluoro-ethyl)-1,2,4-oxadiazol-3-yl]-8-fluoro-5-[(4-isopropoxyphenyl)methyl]-1,1-dioxo-2,3-dihydro-1λ6,5-benzothiazepin-4-one::US20240368150, Example 48

SMILES CC(C)Oc1ccc(CN2C(=O)[C@@H](N)CS(=O)(=O)c3cc(F)c(-c4noc(C(N)C(F)(F)F)n4)cc32)cc1

InChI Key InChIKey=SWOFOOZAFQLOKF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 703778   

TargetDiacylglycerol kinase alpha(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703778((3R)-3-amino-7-[5-(1-amino-2,2,2-trifluoro-ethyl)-...)
Affinity DataIC50: 403nMAssay Description:DGK α and ζ kinase use ATP to phosphorylate the substrate 1,2-dilauroyl-sn-glycerol (DLG, incorporated in the liposomes). ATP is converted to ADP as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM703778((3R)-3-amino-7-[5-(1-amino-2,2,2-trifluoro-ethyl)-...)
Affinity DataIC50: 114nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent