BDBM702805 ((1S,2R)-2-fluorocyclopropyl)(3-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone::US20240360157, Example 159

SMILES Cn6cc(c5cc4c(N1CC2CCC(C1)N2C(=O)[C@@H]3C[C@H]3F)ncnn4c5)cn6

InChI Key InChIKey=LASPCOZKXNBETL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 702805   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702805(((1S,2R)-2-fluorocyclopropyl)(3-(6-(1-methyl-1H-py...)
Affinity DataIC50: 1.10nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Biogen Ma

US Patent
LigandPNGBDBM702805(((1S,2R)-2-fluorocyclopropyl)(3-(6-(1-methyl-1H-py...)
Affinity DataIC50: 51nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702805(((1S,2R)-2-fluorocyclopropyl)(3-(6-(1-methyl-1H-py...)
Affinity DataIC50: 30nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [3-974](Human)
Biogen Ma

US Patent
LigandPNGBDBM702805(((1S,2R)-2-fluorocyclopropyl)(3-(6-(1-methyl-1H-py...)
Affinity DataIC50: 263nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent