BDBM702762 US20240360157, Example 116

SMILES O=C([C@@H]1C[C@H]1F)N1C2CCC1CN(c1ccnn3cc(-c4ccc(C(F)F)nc4)cc13)C2

InChI Key InChIKey=JPQBWHXKPJOPGH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 702762   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702762(US20240360157, Example 116)
Affinity DataIC50: 2.60nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Biogen Ma

US Patent
LigandPNGBDBM702762(US20240360157, Example 116)
Affinity DataIC50: 44nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702762(US20240360157, Example 116)
Affinity DataIC50: 41nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [3-974](Human)
Biogen Ma

US Patent
LigandPNGBDBM702762(US20240360157, Example 116)
Affinity DataIC50: 847nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent