BDBM701603 US20240352053, Compound Formula I

SMILES COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nc(C4CC4)ccc3c2P(C)(C)=O)n1

InChI Key InChIKey=DKMXEBIKMPYHST-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 701603   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM701603(US20240352053, Compound Formula I)
Affinity DataIC50: 0.300nMAssay Description:Mobility shift assays were performed to determine the compound's inhibitory activity against EGFR delta19del/T790M/C797S, EGFR WT, and IGF1R kinases....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM701603(US20240352053, Compound Formula I)
Affinity DataIC50: 20.2nMAssay Description:Mobility shift assays were performed to determine the compound's inhibitory activity against EGFR delta19del/T790M/C797S, EGFR WT, and IGF1R kinases....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM701603(US20240352053, Compound Formula I)
Affinity DataIC50: 195nMAssay Description:Mobility shift assays were performed to determine the compound's inhibitory activity against EGFR delta19del/T790M/C797S, EGFR WT, and IGF1R kinases....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent