BDBM701602 US20240352053, Compound Control Example 1

SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc4ncccc4c3P(C)(C)=O)n2)c(OC)cc1N1CCC(N2CCN(C)CC2)CC1

InChI Key InChIKey=UJVYDMJHGODRML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 701602   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM701602(US20240352053, Compound Control Example 1)
Affinity DataIC50: 0.200nMAssay Description:Mobility shift assays were performed to determine the compound's inhibitory activity against EGFR delta19del/T790M/C797S, EGFR WT, and IGF1R kinases....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM701602(US20240352053, Compound Control Example 1)
Affinity DataIC50: 5.10nMAssay Description:Mobility shift assays were performed to determine the compound's inhibitory activity against EGFR delta19del/T790M/C797S, EGFR WT, and IGF1R kinases....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM701602(US20240352053, Compound Control Example 1)
Affinity DataIC50: 9.5nMAssay Description:Mobility shift assays were performed to determine the compound's inhibitory activity against EGFR delta19del/T790M/C797S, EGFR WT, and IGF1R kinases....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent