BDBM701467 US20240352000, Example 13

SMILES CCS(=O)(=O)N1CCc2cccc(Nc3nc(Nc4ccc(N5CCC(N6CCN(C)CC6)CC5)cc4OC)ncc3Cl)c21

InChI Key InChIKey=DELOUQHTNUAKHK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 701467   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701467(US20240352000, Example 13)
Affinity DataIC50: 1nMAssay Description:An experiment to measure the activity of the compounds of the present invention against EGFR mutant enzymes was performed as follows using the HTRF s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701467(US20240352000, Example 13)
Affinity DataIC50: 1nMAssay Description:An experiment to measure the activity of the compounds of the present invention against EGFR mutant enzymes was performed as follows using the HTRF s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701467(US20240352000, Example 13)
Affinity DataIC50: 91nMAssay Description:An experiment to measure the activity of the compounds of the present invention against EGFR mutant enzymes was performed as follows using the HTRF s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701467(US20240352000, Example 13)
Affinity DataIC50: 26nMAssay Description:An experiment to measure the activity of the compounds of the present invention against HER mutant enzymes was performed as follows using the HTRF sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent