BDBM701243 4-(2-((3,3-difluorocyclohexyl)(phenyl)amino)- 2-oxoethyl)-1-(pyridin-2-yl)piperidine-4- carboxylic acid::US12122750, Example 74B

SMILES O=C(CC1(C(=O)O)CCN(c2ccccn2)CC1)N(c1ccccc1)C1CCCC(F)(F)C1

InChI Key InChIKey=NATGVHJTUMBGDG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 701243   

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701243(4-(2-((3,3-difluorocyclohexyl)(phenyl)amino)- 2-ox...)
Affinity DataKi:  1.28nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

TargetType-1 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701243(4-(2-((3,3-difluorocyclohexyl)(phenyl)amino)- 2-ox...)
Affinity DataKi: >4.99E+4nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent