BDBM700930 US20240343694, Example 58::tert-butyl (2-((2-acrylamido-4-((5- chloro-4-((1-(methylsulfonyl)- 1,2,3,4-tetrahydroquinolin-8- yl)amino)pyrimidin-2-yl)amino)-5- methoxyphenyl)(methyl)amino) ethyl)(methyl)carbamate

SMILES C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3cccc4c3N(S(C)(=O)=O)CCC4)n2)c(OC)cc1N(C)CCN(C)C(=O)OC(C)(C)C

InChI Key InChIKey=POGVJKDNNKLOEI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 700930   

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700930(tert-butyl (2-((2-acrylamido-4-((5- chloro-4-((1-(...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700930(tert-butyl (2-((2-acrylamido-4-((5- chloro-4-((1-(...)
Affinity DataIC50: 10nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700930(tert-butyl (2-((2-acrylamido-4-((5- chloro-4-((1-(...)
Affinity DataIC50: 90nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent