BDBM6995 4-[4-(tert-butylamino)-2-(trifluoromethyl)quinazolin-6-yl]phenol::6-substituted quinazoline 45

SMILES CC(C)(C)Nc1nc(nc2ccc(cc12)-c1ccc(O)cc1)C(F)(F)F

InChI Key InChIKey=LTQLIQSYQBQFSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6995   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6995(4-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 700nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6995(4-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.10E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed