BDBM699416 2-chloro-1-[3-[4-[(1R)-1,2- dihydroxyethyl]-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-3-yl]azetidin-1-yl]prop-2-en- 1-one::US12110276, Compound 110

SMILES OC[C@H](O)c1ccnc2n(nc(C3CN(C3)C(=O)C(Cl)=C)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=LZINKSRQWFTLRX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699416   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699416(2-chloro-1-[3-[4-[(1R)-1,2- dihydroxyethyl]-1-[4- ...)
Affinity DataIC50: 19nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699416(2-chloro-1-[3-[4-[(1R)-1,2- dihydroxyethyl]-1-[4- ...)
Affinity DataIC50: 8nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699416(2-chloro-1-[3-[4-[(1R)-1,2- dihydroxyethyl]-1-[4- ...)
Affinity DataIC50: 17nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699416(2-chloro-1-[3-[4-[(1R)-1,2- dihydroxyethyl]-1-[4- ...)
Affinity DataIC50: 4.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent