BDBM699359 (Z)-3-chloro-N-[[4-[(1S)-1,2- dihydroxyethyl]-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-3-yl]methyl]prop-2-enamide::US12110276, Compound 53

SMILES OC[C@@H](O)c1ccnc2n(nc(CNC(=O)\C=C/Cl)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=WLQCJPPBRDDTTG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699359   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699359((Z)-3-chloro-N-[[4-[(1S)-1,2- dihydroxyethyl]-1-[4...)
Affinity DataIC50: 45nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699359((Z)-3-chloro-N-[[4-[(1S)-1,2- dihydroxyethyl]-1-[4...)
Affinity DataIC50: 36nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699359((Z)-3-chloro-N-[[4-[(1S)-1,2- dihydroxyethyl]-1-[4...)
Affinity DataIC50: 5.00E+4nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699359((Z)-3-chloro-N-[[4-[(1S)-1,2- dihydroxyethyl]-1-[4...)
Affinity DataIC50: 3.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent