BDBM699307 5-Ethyl-4-((5aR,6S,9R)-1-fluoro-12-(((2R,7aS)- 2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl) methoxy)-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a, 11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab] heptalen-2-yl)naphthalen-2-ol 12-p1::US20240327434, Compound 12-p1

SMILES CCc1cccc2cc(O)cc(-c3nc4OC[C@H]5[C@@H]6CC[C@H](CN5c5nc(OC[C@@]78CCCN7C[C@H](F)C8)nc(c3F)c45)N6)c12

InChI Key InChIKey=ZEYGRDXDMAILNT-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699307   

TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699307(5-Ethyl-4-((5aR,6S,9R)-1-fluoro-12-(((2R,7aS)- 2-f...)
Affinity DataKd:  0.300nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699307(5-Ethyl-4-((5aR,6S,9R)-1-fluoro-12-(((2R,7aS)- 2-f...)
Affinity DataKd:  7.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent