BDBM699304 3-Chloro-4-cyclopropyl-5-((5aS,6S,9R)-1-fluoro- 12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin- 7a(5H)-yl)methoxy)-5a,6,7,8,9,10-hexahydro- 5H-4-oxa-3,10a,11,13,14-pentaaza-6,9- methanonaphtho[1,8-ab]heptalen-2-yl)phenol 6-p1::US20240327434, Compound 6-p1

SMILES Oc1cc(Cl)c(C2CC2)c(c1)-c1nc2OC[C@@H]3[C@@H]4CC[C@H](CN3c3nc(OC[C@@]56CCCN5C[C@H](F)C6)nc(c1F)c23)N4

InChI Key InChIKey=YJEQGJQGIRWMAT-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699304   

TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699304(3-Chloro-4-cyclopropyl-5-((5aS,6S,9R)-1-fluoro- 12...)
Affinity DataKd:  0.100nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699304(3-Chloro-4-cyclopropyl-5-((5aS,6S,9R)-1-fluoro- 12...)
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent