BDBM699302 5-Ethyl-4-((5aS,6S,9R)-12-(((2R,7aS)-2- fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)- 5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13, 14-pentaaza-6,9-methanonaphtho[1,8-ab] heptalen-2-yl)naphthalen-2-ol 2-p1::US20240327434, Compound 2-p1

SMILES CCc1cccc2cc(O)cc(-c3cc4nc(OC[C@@]56CCCN5C[C@H](F)C6)nc5N6C[C@H]7CC[C@H](N7)[C@H]6COc(n3)c45)c12

InChI Key InChIKey=BIDMYSWBFSKYQE-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699302   

TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699302(5-Ethyl-4-((5aS,6S,9R)-12-(((2R,7aS)-2- fluorotetr...)
Affinity DataKd:  0.400nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699302(5-Ethyl-4-((5aS,6S,9R)-12-(((2R,7aS)-2- fluorotetr...)
Affinity DataKd:  32.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent