BDBM699200 US12145945, Example 40::US20240327430, Example 40

SMILES COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nc2ccc(cc2s1)C1(O)CCOC1

InChI Key InChIKey=NBRJTSUGPTUKAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699200   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699200(US20240327430, Example 40 | US12145945, Example 40)
Affinity DataIC50: 550nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Pol&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699200(US20240327430, Example 40 | US12145945, Example 40)
Affinity DataIC50: 550nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Polθ protein (P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2025
Entry Details
Go to US Patent