BDBM699192 BDBM699228::US20240327430, Example 33

SMILES COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nc2cnc(nc2s1)N1CCC(O)CC1

InChI Key InChIKey=LYRYYYROPIDNJS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699192   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699192(BDBM699228 | US20240327430, Example 33)
Affinity DataIC50: 1.00E+3nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Pol&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699192(BDBM699228 | US20240327430, Example 33)
Affinity DataIC50: 1.00E+3nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Pol&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent