BDBM699143 US20240327425, Compound I-12-1

SMILES CC(C)(C)OC(=O)Nc1nc2c(cccc2s1)-c1c(Cl)c2OC[C@@H]3[C@@H]4CC[C@H](CN3c3nc(OC[C@@]56CCCN5C[C@H](F)C6)nc(c1F)c23)N4

InChI Key InChIKey=MELFISLCGUGRSG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 699143   

TargetGTPase KRas [G12D](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM699143(US20240327425, Compound I-12-1)
Affinity DataIC50: 30.3nMAssay Description:The binding ability of the compound to KRAS G12D protein was detected by TR-FRET method, and the inhibitory activity of the compound on KRAS G12D pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent