BDBM698959 2-(2-Fluoro-4-iodoanilino)-5-[[3-fluoro-2-(methylsulfamoylamino)pyri din-4-yl]methyl]-1-methyl-6-oxopyridine-3-carboxamide::US20240327355, Compound J-1

SMILES CNS(=C)(=O)Nc1nccc(Cc2cc(C(N)=O)c(Nc3ccc(I)cc3F)n(C)c2=O)c1F

InChI Key InChIKey=WFLXIWOCFBMJNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698959   

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM698959(2-(2-Fluoro-4-iodoanilino)-5-[[3-fluoro-2-(methyls...)
Affinity DataIC50: 58nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
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Date in BDB:
2/3/2025
Entry Details
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TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM698959(2-(2-Fluoro-4-iodoanilino)-5-[[3-fluoro-2-(methyls...)
Affinity DataIC50: 4nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 6 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent