BDBM698958 4-Fluoro-2-(2-fluoro-4-iodoanilino)-5-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]benzamide::US20240327355, Compound I-1

SMILES CNS(=O)(=O)Nc1nccc(Oc2cc(C(N)=O)c(Nc3ccc(I)cc3F)cc2F)c1F

InChI Key InChIKey=ZGWQEJGAIHLJAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698958   

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM698958(4-Fluoro-2-(2-fluoro-4-iodoanilino)-5-[[3-fluoro-2...)
Affinity DataIC50: 25nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM698958(4-Fluoro-2-(2-fluoro-4-iodoanilino)-5-[[3-fluoro-2...)
Affinity DataIC50: 3nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 6 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent