BDBM698738 BDBM698739::US20240317721, Example 318a

SMILES CC(=O)N1CC2CCC(C1)N2C[C@@H]1CCN(c2nn(C3CC4(C3)CN(C4)C(=O)C=C)c(C)c2-c2c(Cl)c(Cl)cc3[nH]ncc23)C(C)(C)C1

InChI Key InChIKey=HFUQXZNCMUXIGX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698738   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698738(US20240317721, Example 318a | BDBM698739)
Affinity DataIC50: 7nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698738(US20240317721, Example 318a | BDBM698739)
Affinity DataIC50: 4.00E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent