BDBM698692 BDBM698693::US20240317721, Example 295a

SMILES CC(=O)N1C[C@@H]2CN(C[C@@H]3CCN(c4nn(C5CC6(C5)CN(C6)C(=O)C=C)c(C)c4-c4c(Cl)c(Cl)cc5[nH]ncc45)C(C)(C)C3)C[C@@H]2C1

InChI Key InChIKey=FQAIJUAKLVWGPU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698692   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698692(BDBM698693 | US20240317721, Example 295a)
Affinity DataIC50: 2.00E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698692(BDBM698693 | US20240317721, Example 295a)
Affinity DataIC50: 6nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent