BDBM698674 BDBM698675::US20240317721, Example 286a

SMILES COC[C@@H]1C[C@@H](O)CN1C[C@@H]1CCN(c2nn(C3CC4(C3)CN(C4)C(=O)C=C)c(C)c2-c2c(Cl)c(Cl)cc3[nH]ncc23)C(C)(C)C1

InChI Key InChIKey=MTIVKYYDQFLRSX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698674   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698674(BDBM698675 | US20240317721, Example 286a)
Affinity DataIC50: 1.10E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698674(BDBM698675 | US20240317721, Example 286a)
Affinity DataIC50: 7nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent