BDBM698642 BDBM698643::US20240317721, Example 270a

SMILES CN1CCN(C[C@@H]2CCN(c3nn(C4CC5(C4)CN(C5)C(=O)C=C)c(C)c3-c3c(Cl)c(Cl)cc4[nH]ncc34)C(C)(C)C2)C[C@H]1CO

InChI Key InChIKey=MNVJCOZAHGIZGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698642   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698642(BDBM698643 | US20240317721, Example 270a)
Affinity DataIC50: 2.40E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698642(BDBM698643 | US20240317721, Example 270a)
Affinity DataIC50: 5nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent