BDBM698638 BDBM698639::US20240317721, Example 268a

SMILES CC(=O)N1CCC2(CN(C[C@@H]3CCN(c4nn(C5CC6(C5)CN(C6)C(=O)C=C)c(C)c4-c4c(Cl)c(Cl)cc5[nH]ncc45)C(C)(C)C3)C2)C1

InChI Key InChIKey=BPMDEVBWTJFYKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698638   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698638(US20240317721, Example 268a | BDBM698639)
Affinity DataIC50: 789nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698638(US20240317721, Example 268a | BDBM698639)
Affinity DataIC50: 7nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent