BDBM698632 BDBM698633::BDBM698634::BDBM698635::US20240317721, Example 265a

SMILES Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)N1CC[C@@H](CN2CCOC3CS(=O)(=O)CC23)CC1(C)C)-c1c(Cl)c(Cl)cc2[nH]ncc12

InChI Key InChIKey=FWHLHSFCXKSIGO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 698632   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698632(BDBM698634 | BDBM698633 | US20240317721, Example 2...)
Affinity DataIC50: 2.90E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698632(BDBM698634 | BDBM698633 | US20240317721, Example 2...)
Affinity DataIC50: 9nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698632(BDBM698634 | BDBM698633 | US20240317721, Example 2...)
Affinity DataIC50: 3.10E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698632(BDBM698634 | BDBM698633 | US20240317721, Example 2...)
Affinity DataIC50: 7nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent