BDBM698405 BDBM698406::US20240317721, Example 150a

SMILES COC[C@@]1(C)CN(CCN1c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(Cl)cc2[nH]ncc12)C1CCOCC1

InChI Key InChIKey=CRKOJIHKCALARH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698405   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698405(US20240317721, Example 150a | BDBM698406)
Affinity DataIC50: 252nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698405(US20240317721, Example 150a | BDBM698406)
Affinity DataIC50: 5nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent