BDBM698334 BDBM698335::BDBM698336::BDBM698337::US20240317721, Example 115a

SMILES CN(C1COC1)C1CCN(c2nn(C3CC4(C3)CN(C4)C(=O)C=C)c(C)c2-c2c(Cl)c(C)cc3[nH]nc(N)c23)C2(CCC2)C1

InChI Key InChIKey=KINIGQGGBZXQJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 698334   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698334(BDBM698335 | BDBM698337 | BDBM698336 | US202403177...)
Affinity DataIC50: 7nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698334(BDBM698335 | BDBM698337 | BDBM698336 | US202403177...)
Affinity DataIC50: 246nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698334(BDBM698335 | BDBM698337 | BDBM698336 | US202403177...)
Affinity DataIC50: 205nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM698334(BDBM698335 | BDBM698337 | BDBM698336 | US202403177...)
Affinity DataIC50: 1.90E+3nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent