BDBM696481 3-(2,3-dichloroanilino)-2-(3-{2-[oxetan-2-yl]ethoxy}pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one::US20240307362, Example 63::US20240307362, Example 64

SMILES Clc1cccc(Nc2c([nH]c3CCNC(=O)c23)-c2ccncc2OCCC2CCO2)c1Cl

InChI Key InChIKey=PBJQSVYLISRMDO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 696481   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696481(US20240307362, Example 63 | 3-(2,3-dichloroanilino...)
Affinity DataIC50: 0.123nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696481(US20240307362, Example 63 | 3-(2,3-dichloroanilino...)
Affinity DataIC50: 0.130nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696481(US20240307362, Example 63 | 3-(2,3-dichloroanilino...)
Affinity DataIC50: 5.51E+3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696481(US20240307362, Example 63 | 3-(2,3-dichloroanilino...)
Affinity DataIC50: 5.38E+3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent