BDBM696455 3-(2-chloro-3-methylanilino)-2-{3-[(oxetan-2-yl)methoxy]pyridin-4-yl}-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one::US20240307362, Example 37

SMILES Cc1cccc(Nc2c([nH]c3CCNC(=O)c23)-c2ccncc2OCC2CCO2)c1Cl

InChI Key InChIKey=HXYQNURBSWYMIH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 696455   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696455(3-(2-chloro-3-methylanilino)-2-{3-[(oxetan-2-yl)me...)
Affinity DataIC50: 0.129nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
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TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696455(3-(2-chloro-3-methylanilino)-2-{3-[(oxetan-2-yl)me...)
Affinity DataIC50: 1.17E+4nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent