BDBM696451 3-(3-bromo-2-methoxyanilino)-2-{3-[(oxetan-2-yl)methoxy]pyridin-4-yl}-1, 5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one::US20240307362, Example 33::US20240307362, Example 34::US20240307362, Example 35

SMILES COc1c(Br)cccc1Nc1c([nH]c2CCNC(=O)c12)-c1ccncc1OCC1CCO1

InChI Key InChIKey=HSEUQTHBEYTMEG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 696451   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696451(US20240307362, Example 33 | 3-(3-bromo-2-methoxyan...)
Affinity DataIC50: 0.142nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696451(US20240307362, Example 33 | 3-(3-bromo-2-methoxyan...)
Affinity DataIC50: 0.157nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696451(US20240307362, Example 33 | 3-(3-bromo-2-methoxyan...)
Affinity DataIC50: 0.278nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696451(US20240307362, Example 33 | 3-(3-bromo-2-methoxyan...)
Affinity DataIC50: 8.06E+3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696451(US20240307362, Example 33 | 3-(3-bromo-2-methoxyan...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696451(US20240307362, Example 33 | 3-(3-bromo-2-methoxyan...)
Affinity DataIC50: 4.97E+3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
Go to US Patent