BDBM696382 1-[(6-{5-azaspiro[2.3]hexan-5-yl}-2-methylpyridin-3-yl)methyl]-N-{[5-chloro-2-(1H-1,2,3,4-tetrazol-1-::US12091399, Example 63

SMILES Cc1nc(ccc1Cn1cc(cn1)C(=O)NCc1cc(Cl)ccc1-n1cnnn1)N1CC2(CC2)C1

InChI Key InChIKey=RZMATAZHFUTRKV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 696382   

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM696382(1-[(6-{5-azaspiro[2.3]hexan-5-yl}-2-methylpyridin-...)
Affinity DataIC50: 0.5nMAssay Description:Human PKK (0.01 U/mL; Enzyme Research Laboratories) or rat PKK (0.625 nM; produced in-house) was incubated for 1 h at rt with 0.10 μM fluorogeni...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/13/2025
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM696382(1-[(6-{5-azaspiro[2.3]hexan-5-yl}-2-methylpyridin-...)
Affinity DataKi:  0.300nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/13/2025
Entry Details
Go to US Patent