BDBM696356 1-[(2-{5-azaspiro[2.3]hexan-5-yl}-4-::US12091399, Example 37

SMILES Cc1nn(Cc2cnc(nc2C)N2CC3(CC3)C2)cc1C(=O)NCc1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=OCTUSJDLMRRNNK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 696356   

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM696356(1-[(2-{5-azaspiro[2.3]hexan-5-yl}-4- | US12091399,...)
Affinity DataIC50: 2nMAssay Description:Human PKK (0.01 U/mL; Enzyme Research Laboratories) or rat PKK (0.625 nM; produced in-house) was incubated for 1 h at rt with 0.10 μM fluorogeni...More data for this Ligand-Target Pair
Ligand InfoSimilars
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Date in BDB:
1/13/2025
Entry Details
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