BDBM696334 7-[(6-{3-azabicyclo[3.1.0]hexan-3-yl}-2-::US12091399, Example 15

SMILES Cc1nc(ccc1Cn1cc(C(=O)NCc2cc(Cl)ccc2-n2cnnn2)c2cncnc12)N1CC2CC2C1

InChI Key InChIKey=QETLWRXTIKJOKZ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 696334   

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM696334(7-[(6-{3-azabicyclo[3.1.0]hexan-3-yl}-2- | US12091...)
Affinity DataIC50: 2nMAssay Description:Human PKK (0.01 U/mL; Enzyme Research Laboratories) or rat PKK (0.625 nM; produced in-house) was incubated for 1 h at rt with 0.10 μM fluorogeni...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/13/2025
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM696334(7-[(6-{3-azabicyclo[3.1.0]hexan-3-yl}-2- | US12091...)
Affinity DataKi:  0.700nMAssay Description:Human PKK (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 f...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/13/2025
Entry Details
Go to US Patent