BDBM696333 1-[(6-{3-azabicyclo[3.1.0]hexan-3-yl}-2-::US12091399, Example 14

SMILES COCc1nn(Cc2ccc(nc2C)N2CC3CC3C2)cc1C(=O)NCc1c(F)c(Cl)ccc1-n1cnnn1

InChI Key InChIKey=DOLROXFQQXRFDG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 696333   

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM696333(1-[(6-{3-azabicyclo[3.1.0]hexan-3-yl}-2- | US12091...)
Affinity DataIC50: 0.600nMAssay Description:Human PKK (0.01 U/mL; Enzyme Research Laboratories) or rat PKK (0.625 nM; produced in-house) was incubated for 1 h at rt with 0.10 μM fluorogeni...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/13/2025
Entry Details
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