BDBM696175 US20240300937, Example 32::US20240300937, Example 39

SMILES CC(C)c1c(CN[C@H]2CCOC2)cnc2ccc(cc12)-c1nc(N[C@@H]2CCOC[C@H]2O)ncc1F

InChI Key InChIKey=QSPGRGDMJHWLAB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 696175   

LigandPNGBDBM696175(US20240300937, Example 32 | US20240300937, Example...)
Affinity DataIC50: 11nMAssay Description:Compounds disclosed herein were tested for inhibition of CDK4/Cyclin D1 or CDK6/Cyclin D3 kinase in an assay based on the time-resolved fluorescence-...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

LigandPNGBDBM696175(US20240300937, Example 32 | US20240300937, Example...)
Affinity DataIC50: 484nMAssay Description:Compounds disclosed herein were tested for inhibition of CDK4/Cyclin D1 or CDK6/Cyclin D3 kinase in an assay based on the time-resolved fluorescence-...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

LigandPNGBDBM696175(US20240300937, Example 32 | US20240300937, Example...)
Affinity DataIC50: 25nMAssay Description:Compounds disclosed herein were tested for inhibition of CDK4/Cyclin D1 or CDK6/Cyclin D3 kinase in an assay based on the time-resolved fluorescence-...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

LigandPNGBDBM696175(US20240300937, Example 32 | US20240300937, Example...)
Affinity DataIC50: 750nMAssay Description:Compounds disclosed herein were tested for inhibition of CDK4/Cyclin D1 or CDK6/Cyclin D3 kinase in an assay based on the time-resolved fluorescence-...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent