BDBM695947 US20240300923, Example 25

SMILES COc1cc2nn(cc2cc1C(=O)Nc1cccn(C)c1=O)[C@H]1CC[C@@H](CC1)c1nnco1

InChI Key InChIKey=WNONSDANAMQJGJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695947   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM695947(US20240300923, Example 25)
Affinity DataIC50: 1.70nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Astrazeneca

US Patent
LigandPNGBDBM695947(US20240300923, Example 25)
Affinity DataIC50: 1.00E+5nMAssay Description:Potency of IRAK4 Inhibitor Compounds in cKit Enzyme Assay. Evaluation of the effects of the IRAK4 inhibitor compounds on the activity of the human cK...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent