BDBM695946 US20240300923, Example 24

SMILES COC1=CC(=N)\C(=C/N[C@H]2CC[C@H](CC2)c2cccnn2)C=C1C(=O)Nc1cccn(C)c1=O

InChI Key InChIKey=FWMROIMRRCYNLB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695946   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM695946(US20240300923, Example 24)
Affinity DataIC50: 1.20nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
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TargetMast/stem cell growth factor receptor Kit(Human)
Astrazeneca

US Patent
LigandPNGBDBM695946(US20240300923, Example 24)
Affinity DataIC50: 8.81E+4nMAssay Description:Potency of IRAK4 Inhibitor Compounds in cKit Enzyme Assay. Evaluation of the effects of the IRAK4 inhibitor compounds on the activity of the human cK...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent