BDBM695900 US20240299360, Example 71-1

SMILES C[C@H]1N(Cc2cc(Cl)c(cc12)C(F)(F)F)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1

InChI Key InChIKey=QMEYEEICXNLCJY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 695900   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695900(US20240299360, Example 71-1)
Affinity DataIC50: 18nMAssay Description:Table 1: A FRET (fluorescence resonance energy transfer) peptide was cleaved by recombinant ADAMTS-4 or ADAMTS-5 proteins into two separate fragments...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695900(US20240299360, Example 71-1)
Affinity DataIC50: 31nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695900(US20240299360, Example 71-1)
Affinity DataIC50: 13nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent