BDBM695889 5-(2-((benzyloxy)methyl)-3-oxo-3-(5-(trifluoromethyl)isoindolin-2-yl)propyl)-5-cyclopropylimidazolidine-2,4-dione 65::US20240299360, Example 65

SMILES FC(F)(F)c1ccc2CN(Cc2c1)C(=O)C(COCc1ccccc1)CC1(NC(=O)NC1=O)C1CC1

InChI Key InChIKey=OACIIQIUQKQGAD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 695889   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695889(US20240299360, Example 65 | 5-(2-((benzyloxy)methy...)
Affinity DataIC50: 16nMAssay Description:Table 1: A FRET (fluorescence resonance energy transfer) peptide was cleaved by recombinant ADAMTS-4 or ADAMTS-5 proteins into two separate fragments...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695889(US20240299360, Example 65 | 5-(2-((benzyloxy)methy...)
Affinity DataIC50: 21nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695889(US20240299360, Example 65 | 5-(2-((benzyloxy)methy...)
Affinity DataIC50: 31nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent