BDBM695871 5-cyclopropyl-5-(3-(5,6-dichloroisoindolin-2-yl)-2-(hydroxymethyl)-3-oxopropyl)imidazolidine-2,4-dione 42::US20240299360, Example 42

SMILES OCC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1Cc2cc(Cl)c(Cl)cc2C1

InChI Key InChIKey=UKSOPPJLMFZIFG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 695871   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695871(US20240299360, Example 42 | 5-cyclopropyl-5-(3-(5,...)
Affinity DataIC50: 11nMAssay Description:Table 1: A FRET (fluorescence resonance energy transfer) peptide was cleaved by recombinant ADAMTS-4 or ADAMTS-5 proteins into two separate fragments...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695871(US20240299360, Example 42 | 5-cyclopropyl-5-(3-(5,...)
Affinity DataIC50: 14nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM695871(US20240299360, Example 42 | 5-cyclopropyl-5-(3-(5,...)
Affinity DataIC50: 17nMAssay Description:Table 2: In this assay, the enzymatic activity of recombinant ADAMTS-5 protein (catalog #2198-AD, R&D Systems) was assayed with a protein substrate, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent