BDBM695705 N-(bicyclo[1.1.1]pentan-1-yl)-2- methoxy-5-(5$#8243;-(methylsulfonamido) dispiro[cyclopropane-1,1'-cyclohexane- 4',3$#8243;-indoline]-1$#8243;- carbonyl)benzenesulfonamide::US12084420, Compound 311

SMILES COc1ccc(cc1S(=O)(=O)NC12CC(C1)C2)C(=O)N1CC2(CCC3(CC3)CC2)c2cc(NS(C)(=O)=O)ccc12

InChI Key InChIKey=WOTBMXKJMVVBQR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 695705   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695705(US12084420, Compound 311 | N-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 5.20nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent