BDBM694722 (7S,15S)-9-(2,6-difluorophenyl)-4-ethyl-7,15-dimethyl-13,16-dioxa-18-thia-2,3,5,8-tetrazatetracyclo[8.8.0.02,6.011,17]octadeca-1(10),3,5,8,11::US20240294543, Example 49

SMILES CCc1nc2[C@H](C)N=C(c3c4COC[C@H](C)Oc4sc3-n2n1)c1c(F)cccc1F

InChI Key InChIKey=MGCCHYUIAWKZSP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694722   

LigandPNGBDBM694722((7S,15S)-9-(2,6-difluorophenyl)-4-ethyl-7,15-dimet...)
Affinity DataKi:  3.32nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694722((7S,15S)-9-(2,6-difluorophenyl)-4-ethyl-7,15-dimet...)
Affinity DataKi:  52.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694722((7S,15S)-9-(2,6-difluorophenyl)-4-ethyl-7,15-dimet...)
Affinity DataKi:  52.5nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694722((7S,15S)-9-(2,6-difluorophenyl)-4-ethyl-7,15-dimet...)
Affinity DataKi:  8.75E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent