BDBM694719 (7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl]-13,16-dioxa-18-thia-2,3,5,8-tetrazatetracyclo[8.8.0.02,6.011,17]octadeca-1(10),3,5,8,11::US20240294543, Example 46

SMILES C[C@@H]1N=C(c2c3COCCOc3sc2-n2nc(nc12)C(=O)NC[C@@](C)(O)C(F)(F)F)c1c(F)cccc1F

InChI Key InChIKey=ZCNSFTYHSWGTSA-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 694719   

LigandPNGBDBM694719((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3...)
Affinity DataKi:  3.54nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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Date in BDB:
12/21/2024
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LigandPNGBDBM694719((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3...)
Affinity DataKi:  15.2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694719((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3...)
Affinity DataKi:  15.2nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694719((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3...)
Affinity DataKi:  60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694719((7S)-9-(2,6-difluorophenyl)-7-methyl-N-[(2R)-3,3,3...)
Affinity DataKi:  4.32E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent