BDBM694710 (7S)-9-(2,6-difluorophenyl)-N-ethyl-7-methyl-13,16-dioxa-18-thia-2,3,5,8-tetrazatetracyclo[8.8.0.02,6.011,17]octadeca-1(10),3,5,8,11::US20240294543, Example 37::US20240294543, Example 38

SMILES CCNC(=O)c1nc2[C@H](C)N=C(c3c4COCCOc4sc3-n2n1)c1c(F)cccc1F

InChI Key InChIKey=ONFCJAJGPCBWRV-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 694710   

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  3.21nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  3.59nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  17.9nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  17.9nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  33.7nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  33.7nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  122nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  4.03E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694710(US20240294543, Example 38 | (7S)-9-(2,6-difluoroph...)
Affinity DataKi:  4.08E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent