BDBM694254 US12077506, Compound I-21a::rac-3-(((2S,3S)-4-(difluoromethyl)-1,1,2-trifluoro-3- hydroxy-2,3-dihydro-1H-inden-5-yl)oxy)-5- fluorobenzonitrile

SMILES O[C@@H]1[C@H](F)C(F)(F)c2ccc(Oc3cc(F)cc(c3)C#N)c(C(F)F)c12

InChI Key InChIKey=VLDMSGGDCPMLHB-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 694254   

TargetVascular endothelial growth factor A(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM694254(rac-3-(((2S,3S)-4-(difluoromethyl)-1,1,2-trifluoro...)
Affinity DataEC50:  34nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2alpha was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
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Date in BDB:
12/16/2024
Entry Details
Go to US Patent