BDBM694232 (R)-3-((3-amino-4-(difluoromethyl)-1,1,2,2- tetrafluoro-2,3-dihydro-1H-inden-5-yl)oxy)-5- fluorobenzonitrile::US12077506, Compound I-3a

SMILES N[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)C(F)(F)C1(F)F

InChI Key InChIKey=PSXYCGZVNZTLEZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 694232   

TargetVascular endothelial growth factor A(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM694232(US12077506, Compound I-3a | (R)-3-((3-amino-4-(dif...)
Affinity DataEC50:  129nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2alpha was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
Go to US Patent