BDBM693453 1-(4-(difluoromethyl)phenyl)-N-(2,3,6- trifluoro-4-((3-(2-(((3S,5S)-5- fluoropiperidin-3-yl)amino)pyrimidin-4- yl)pyridin-2- yl)oxy)phenyl)methanesulfonamide::US12071425, Compound 371

SMILES FC(F)c1ccc(CS(=O)(=O)Nc2c(F)cc(Oc3ncccc3-c3ccnc(N[C@@H]4CNC[C@@H](F)C4)n3)c(F)c2F)cc1

InChI Key InChIKey=ULYOCUZFOSIYKP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 693453   

LigandPNGBDBM693453(1-(4-(difluoromethyl)phenyl)-N-(2,3,6- trifluoro-4...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
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Date in BDB:
12/6/2024
Entry Details
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