BDBM693446 1-(4-chloro-2-fluoro-phenyl)-N-[2,3,6- trifluoro-4-[[3-[2-[[(3S,5S)-5-fluoro-3- piperidyl]amino]pyrimidin-4-yl]-2- pyridyl]oxy]phenyl]methanesulfonamide::US12071425, Compound 364

SMILES F[C@@H]1CNC[C@H](C1)Nc1nccc(n1)-c1cccnc1Oc1cc(F)c(NS(=O)(=O)Cc2ccc(Cl)cc2F)c(F)c1F

InChI Key InChIKey=AKNCJONTAIKIDC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 693446   

LigandPNGBDBM693446(1-(4-chloro-2-fluoro-phenyl)-N-[2,3,6- trifluoro-4...)
Affinity DataIC50: 0.300nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
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Date in BDB:
12/6/2024
Entry Details
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