BDBM693415 1-phenyl-N-(2,3,6-trifluoro-4-((3-(2-((5- (2-fluoropropan-2-yl)piperidin-3- yl)amino)pyrimidin-4-yl)pyridin-2- yl)oxy)phenyl)methanesulfonamide hydrochloride::US12071425, Compound 333::US12071425, Compound 334::US12071425, Compound 335::US12071425, Compound 336

SMILES CC(C)(F)C1CNCC(C1)Nc1nccc(n1)-c1cccnc1Oc1cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c1F

InChI Key InChIKey=GGKYXXBOAOQLQX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 693415   

LigandPNGBDBM693415(US12071425, Compound 334 | US12071425, Compound 33...)
Affinity DataIC50: 0.190nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
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LigandPNGBDBM693415(US12071425, Compound 334 | US12071425, Compound 33...)
Affinity DataIC50: 9.80nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent

LigandPNGBDBM693415(US12071425, Compound 334 | US12071425, Compound 33...)
Affinity DataIC50: 330nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent

LigandPNGBDBM693415(US12071425, Compound 334 | US12071425, Compound 33...)
Affinity DataIC50: 0.420nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
Go to US Patent